The intraocular pressure reducing effect of latanoprost has been shown to be additive to that of beta-adrenergic antagonists (timolol), adrenergic agonists (dipivalyl epinephrine), carbonic anhydrase inhibitors (acetazolamide), and at least partly to cholinergic agonists (pilocarpine). There have been reports of paradoxical elevations in IOP following the concomitant ophthalmic administration of two prostaglandin analogues. Therefore, the use of two or more prostaglandins, prostaglandin analogues, or prostaglandin derivatives is not recommended.
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